Do you mean fancy signature URLs for gif images?
If that's the case, you need to find and edit the htaccess.txt file included with the script. Open the file and find:
Change /adoptables200/ to the directory relative to the root of your site where the adoptables script is installed. If it's installed at the root it would just be / or if something like in a folder named adopts it would be /adopts/ .
Then upload to the folder where you installed the adoptables script and rename it just
.htaccess. You can also rename it in notepad by saving as ".htaccess" with the quotes to force the new filetype. :)